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Research Team From the Faculty of Science in Prague Found Promising Results for Nuclear Medicine

Nicole Choquette by Nicole Choquette
February 27, 2021
in Technology ☆ Science
A A
Research Team From the Faculty of Science in Prague Found Promising Results for Nuclear Medicine

Assoc. Prof. RNDr. Vojtěch Kubíček, Ph.D. Deputy of the head of the department. © Charles University

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Cross-bridged cyclam derivatives bearing two phosphonate, bis(phosphinate), or phosphinate pendant arms were synthesized and studied with respect to their application as copper radioisotope carriers in nuclear medicine.

The ligands show high macrocycle basicity and high copper complex stability. The complexation and dissociation kinetics of the copper complexes were studied by ultraviolet–visible spectroscopy. Phosphonate and bis(phosphinate) copper complexes form very quickly, reaching quantitative formation in few seconds. Conversely, the formation of the phosphinate complex is much slower due to the low stability of the reaction intermediate.

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All studied complexes are highly kinetically inert. The high thermodynamic stability, fast formation, and extreme kinetic inertness of the complexes indicate that phosphonate and bis(phosphinate) derivatives are promising ligands for nuclear medicine.

Nuclear medicine is a medical specialty involving the application of radioactive substances in the diagnosis and treatment of disease. Nuclear medicine imaging, in a sense, is “radiology done inside out” or “endoradiology” because it records radiation emitting from within the body rather than radiation that is generated by external sources like X-rays. In addition, nuclear medicine scans differ from radiology, as the emphasis is not on imaging anatomy, but on the function.

Read more in the original ​research article ​published in Inorganic Chemistry.

Faculty of Science in Prague

The Faculty of Science​ was established in 1920 as the fifth faculty of Charles University. It currently has 29 departments, 3 museums and a large Botanical Garden where the Study Department and some students’ facilities are located.

Nowadays the faculty is academically and organizationally divided into four sections: biological, geographical, geological and chemical. In addition to these sections the faculty has several specialized teaching and research centres, including interdisciplinary institutions such as the Institute for Environmental Studies. All parts of the faculty are active in both teaching and research.

Nicole Choquette

Nicole Choquette

Assistant Managing Editor

Belmont Newsroom

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